The Effect of Greater Celandine Active Ingredient Chelidonine on Isolated Rat Bladder and Trachea Smooth Muscles and Primary Lung and Kidney Cell Lines

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dc.contributor.authorArslanbas, Emre
dc.contributor.authorKara, Haki
dc.contributor.authorTurgut, Nergiz Hacer
dc.contributor.authorGungor, Huseyin
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorAtasoy, Mustafa Ozan
dc.contributor.authorKumru, Alper Serhat
dc.date.accessioned2024-10-26T18:00:07Z
dc.date.available2024-10-26T18:00:07Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study aims to explore the pharmacodynamics of chelidonine, the active ingredient in greater celandine (Chelidonium majus L.), on in vitro rat bladder and trachea tissue, and evaluate its cell protective effects on primary lung and kidney cell lines. The study was carried out via repeated applications of acetylcholine, atropine, verapamil and oxybutynin, alongside Ca++ in a calcium-free environment, on urinary bladder tissue, and repeated applications of acetylcholine, atropine, carbachol and mecamylamine on trachea tissue. At the same time, cell viability and catalase and superoxide dismutase activity was measured on primary cell lines obtained from lung and kidney tissue samples. The study has shown that chelidonine has a relaxant effect on bladder and trachea tissues, and it may be mentioned that this effect is produced via muscarinic receptors. In addition, chelidonin caused a statistically insignificant increase in cell viability in primary lung and kidney cell lines at increasing doses (1 and 4 mu g/mL), but this increase remained at the control group level. In contrast, chelidonin caused a significant decrease in cell viability at the same cell lines at doses of 8 and 16 mu g/mL. In conclusion, it is suggested that greater celandine, which is used in folk medicine, and its active ingredient chelidonine might have beneficial effects on asthma, urinary incontinence and other urinary tract and respiratory diseases among others.
dc.identifier.doi10.9775/kvfd.2020.24286
dc.identifier.endpage704
dc.identifier.issn1300-6045
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85089713535
dc.identifier.scopusqualityQ3
dc.identifier.startpage697
dc.identifier.trdizinid364972
dc.identifier.urihttps://doi.org/10.9775/kvfd.2020.24286
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/364972
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27539
dc.identifier.volume26
dc.identifier.wosWOS:000562133000016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChelidonine
dc.subjectUrinary bladder
dc.subjectTrachea tissue
dc.subjectSmooth muscle
dc.subjectCell culture
dc.subjectRat
dc.titleThe Effect of Greater Celandine Active Ingredient Chelidonine on Isolated Rat Bladder and Trachea Smooth Muscles and Primary Lung and Kidney Cell Lines
dc.typeArticle

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