Efficacy of mirtazapine in neuropathic pain model

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dc.contributor.authorFigul Gokce, Seyda
dc.contributor.authorCigdem, Burhanettin
dc.date.accessioned2024-10-26T18:00:10Z
dc.date.available2024-10-26T18:00:10Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Neuropathic pain, which is chronic pain, can affect the quality of life individuals. It can cause psychiatric problems such as depression and anxiety. Mirtazapine is an atypical antidepressant which has both noradrenergic and specific serotonergic receptor antagonism and shown to have anxiolytic, anti-emetic and appetite stimulating effects along with its antidepressant effect. It is generally tolerated better and has a different way of action when compared with other antidepressants used to treat neuropathic pain. Thus, we aimed to investigate its potential preventive effect in neuropathic pain in nerve ligated rat model. Methods: Forty rats were divided into five groups including the sham, the sciatic nerve ligation group and the third, fourth and fifth sciatic nerve ligation+mirtazepine groups which were treated with 5 mg, 10 mg and 15 mg/day mirtazapine, respectively. The tail flick and hot plate tests were performed on all the five groups, and the latency times were measured. Morphine was used as a positive control agent. Results: Administration of mirtazapine, restored both tail flick and hot plate latencies in a dose-dependent manner, meaning that mirtazapine is effective in treating neuropathic pain in this animal model. Mirtazapine also restored the antinociceptive response to morphine significantly. Discussion: Mirtazapine appears to be good candidate for both neuropathic pain treatment and accompanying psychiatric condition such as depression and anxiety with its dual effect on neurotransmitters.
dc.identifier.doi10.5455/apd.82305
dc.identifier.endpage467
dc.identifier.issn1302-6631
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85087925317
dc.identifier.scopusqualityQ4
dc.identifier.startpage461
dc.identifier.trdizinid379120
dc.identifier.urihttps://doi.org/10.5455/apd.82305
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/379120
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27560
dc.identifier.volume21
dc.identifier.wosWOS:000541815600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal of Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmirtazapine
dc.subjectneuropathic pain
dc.titleEfficacy of mirtazapine in neuropathic pain model
dc.typeArticle

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