In Vitro Evaluation of the Chemical Composition and Various Biological Activities of Ficus carica Leaf Extracts

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dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authoridErgul, Mustafa/0000-0003-4303-2996
dc.authoridAtas, Mehmet/0000-0002-9425-0080
dc.authoridUcar, Esra/0000-0001-6327-4779
dc.contributor.authorErgul, Mustafa
dc.contributor.authorErgul, Merve
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAtas, Mehmet
dc.contributor.authorUcar, Esra
dc.date.accessioned2024-10-26T18:00:05Z
dc.date.available2024-10-26T18:00:05Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: The present study aimed to investigate the inhibitory activities of enzymes related to diabetes mellitus and Alzheimer's disease of the methanol and water extracts of Ficus carica leaf extracts. The bioactive compounds and anticancer, antioxidant, and antimicrobial effects of the extracts were also investigated. Materials and Methods: The bioactive compounds in the extracts were determined by gas chromatography-mass spectrometry. The antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6 sulphonic acid) (ABTS) radical scavenging, total phenol and flavonoid content, ferric reducing power, and iron chelating method. The anticancer, anticholinesterase, and antimicrobial effects were investigated using the XTT assay, Ellman method, and microdilution, respectively. Results: Our results showed that between the water and methanol extracts there was a difference in terms of chemical composition. The antioxidant results suggested that both extracts have strong antioxidant activity. Similarly, both extracts showed strong alpha-glucosidase and alpha-amylase inhibition activity, while the water extract had higher inhibition activity than the methanol extract against acetylcholinesterase and butyrylcholinesterase. The methanol extract of F. carica exhibited significant anticancer activity on MDA-MB-231 cells and showed moderate antimicrobial activities against Escherichia coli and Staphylococcus aureus. Conclusion: Our results suggest that F. carica leaves could be a valuable source for developing a promising therapeutic agent in cancer, diabetes, and Alzheimer's disease.
dc.identifier.doi10.4274/tjps.galenos.2018.70037
dc.identifier.endpage409
dc.identifier.issn1304-530X
dc.identifier.issue4
dc.identifier.pmid32454742
dc.identifier.scopus2-s2.0-85076514713
dc.identifier.scopusqualityQ3
dc.identifier.startpage401
dc.identifier.trdizinid354301
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2018.70037
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/354301
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27519
dc.identifier.volume16
dc.identifier.wosWOS:000496508100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Pharmacists Assoc
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFicus carica
dc.subjectAlzheimer's disease
dc.subjectdiabetes
dc.subjectantioxidant activity
dc.subjectanticancer and antimicrobial activities
dc.titleIn Vitro Evaluation of the Chemical Composition and Various Biological Activities of Ficus carica Leaf Extracts
dc.typeArticle

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