Klinik Öncesi Bilimleri Bölümü
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Güncel Gönderiler
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The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats
(04.01.2023)Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine ... -
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16.08.2023)Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ... -
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats
(20.02.2023)Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on ... -
The effects of sorafenib in healthy and cisplatin-treated rats
(07.10.2023)Background. Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer. Objectives. The literature on this agent is scarce. This study aimed ... -
FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease
(22.07.2023)Alzheimer’s disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) ... -
Effects of Lavender (Lavandula Angustifolia) Essential Oil on Fattening Performance, Meat Quality, Serum Antioxidant Enzymes, Gut Microbiota and Intestinal Histomorphology in Japanese Quails
(31.07.2023)This study examined the effects of lavender essential oil on performance, meat quality, microbial load, fatty acid profile and gut microbiota in quails. In the study, 200 quails (Coturnix coturnix Japonica) were divided ... -
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line
(28.04.2023)Colorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative of hydroxycinnamic acid, is a promising phytochemical exhibiting numerous pharmacological activities ... -
Prevalence of Shiga Toxin-Producing O157 and Non-O157 Escherichia coli in Anatolian Buffaloes (Bubalus bubalis)
(2023)Shiga toxin producing Escherichia coli (STEC) serotypes are recognized as potentially important food-borne pathogens for humans. Ingestion of E. coli contaminated food is largely known to originate from livestock. Cattle ... -
The effects of low‑level laser therapy on polycystic ovarian syndrome in rats: three diferent dosages
(Ağustos 20)The main objective of this in vivo study was to investigate the efect of diferent low-level laser therapy (LLLT) doses on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol ... -
Parthenolide as a potential analgesic in the treatment of paclitaxel‑induced neuropathic pain: the rat modeling
(Haziran 20)In this study, we determined the therapeutic efect of parthenolide (PTL), the active component of Tanacetum parthenium, on neuropathic pain caused by paclitaxel (PTX), a chemotherapeutic drug frequently used in cancer ... -
FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer’s disease
(Temmuz 202)Alzheimer’s disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyper phosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) ... -
Evaluated periodontal tissues and oxidative stress in rats with neuropathic pain-like behavior
(Ekim 2023)Background Oxidative stress has a critical effect on both persistent pain states and periodontal disease. Voltage-gated sodium NaV1.7 (SCN9A), and transient receptor potential ankyrin 1 (TRPA1) are pain genes. The goal ... -
Comparison of three different dosages of low-level laser therapy on expression of cell proliferation and inflammatory markers following ovariohysterectomy in rats
(Eylül 2023)The objective of the current study was to evaluate Low-level laser therapy (LLLT) on the healing of incisional wounds following ovariohysterectomy in rats, by means of subjective histopathological and immunohistochemical ... -
Assessment of antimicrobial activity and In Vitro wound healing potential of ZnO nanoparticles synthesized with Capparis spinosa extract
(Ekim 2023)Agents that will accelerate wound healing maintain their clinical importance in all aspects. The aim of this study is to deter mine the antimicrobial activity of zinc oxide nanoparticles (ZnO NPs) ZnO nanoparticles obtained ... -
Anticancer activity of lycopene in HT‑29 colon cancer cell line
(Mart 2023)An inverse association between serum lycopene levels and the risk of cancers has been pointed out by many prospective and retrospective epidemiological studies which prompted more studies to be performed on animal models ... -
Lipid-lowering, antiinflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
(05/2023)Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen (APAP) induced hepatotoxicity is still ... -
Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity in rats
(26/07/2023)Cadmium is a major environmental pollutant and a highly toxic metal. It was aimed to determine the effects of pomegranate peel extract (PPE), N-acetylcysteine (NAC) alone and along with Ornipural on cadmium-induced ... -
Kaempferol and Isorhamnetin alleviate Lipopolysaccharide-Induced Anxiety and Depression-Like Behavioral in Balb/C Mice
(09/07/2023)The etiology of anxiety and depression is linked to inflammation and oxidative stress. Isorhamnetin and Kaempferol are strong antioxidants with anti-inflammatory neuroprotective properties. This study, it was aimed to ... -
Carvacrol Mitigates Bleomycin Induced Experimental Pulmonary Fibrosis
(23/08/2023)Idiopathic pulmonary fibrosis (IPF) is a serious progressive pulmonary disease of unknown etiology and high mortality. Carvacrol is a natural phenolic monoterpene with various pharmacological effects, especially antioxidant ... -
Molecular survey of Anaplasma phagocytophilum and related variants in water buffaloes: The first detection of Anaplasma phagocytophilum-like 1
(2023)Anaplasma phagocytophilum infects various hosts and lead to mild to severe infection. Currently, two A.phagocytophilum-related variants have been documented in different countries. Although limited, there are studies ...