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Tetra-substituted phthalocyanines bearing thiazolidine derivatives: synthesis, anticancer activity on different cancer cell lines, and molecular docking studies
(2021)
In the first step, (4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid (c) and 2-(2-(3,4-dicyano phenoxy)phenyl)thiazolidine-4-carboxylic acid (1) were prepared. Then, the peripherally tetra-substituted
metallophthalocyanines ...
Potential role of immune cell genetic variants associated with tumor microenvironment response in laryngeal squamous cell carcinoma (LSCC) in terms of clinicopathological features
(20 October)
Immunomodulatory signals regulate the self-tolerance, activation, priming and survival processes of T cells.
Programmed cell death protein 1 (PD1), Programmed death-ligand 1 (PD-L1) inhibitory signals and CD27, CD28 ...
Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis
(2021)
Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas
outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely
accurate diagnosis ...
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
(1April 202)
Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity,
we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ...
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(2021)
A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized
from KOtBu mediated Michael/Michael addition reaction of 2-
benzylidene-1-indanones with ...
Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects
(2021)
: In this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives
were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities
of the compounds were ...
Selective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells
(2021)
Paclitaxel (PTX) is one of the most effective drugs in the treatment of cancer. However, its usability is limited due
to low solubility and side effects. In this study, we investigated anticancer effects of PTX bonded ...
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(Royal Society of Chemistry, 21.09.2022)
In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral
metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6),
and ...
The role of cytokeratin 19 levels in the determination of endometriosis stages
(2022)
Objective/Aim: Endometrisosis, one of the most common gynecological disease, is characterized by
the presence of endometriotic tissue outside of uterine cavity. The development and the validation
of a simple blood ...
A new method for synthesis of carbon nanoparticle and its applications
(2022)
In the present study, we synthesized carbon nanoparticles with a different method using chi tosan, a natural polymer. As a result, carbon nanomaterials were diffused directly through the
intestinal membrane, and carbon ...