Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Author "Eczacılık Fakültesi"
Now showing items 81-100 of 118
-
Plant‑inspired adhesive and injectable natural hydrogels: in vitro and in vivo studies
Bohórquez‑Moreno,Cristian Daniel; Öksüz, Kerim Emre; Dinçer, Emine; Hepokur, Ceylan; Şen, İlker (2023)The development of alternative thera peutic treatments based on the use of medicinal and aromatic plants, such as Juniper communis L., has aroused interest in the medical feld to fnd new alter natives to conventional ... -
Poli[Maleik Anhidrit-Ko-Vinil Asetat] Kopolimerinin Doksorubisin/Doksorubisin Türevi Antikanser İlaçlarla Doğrusal Rasyonel Konjugatlarının Sentezi, Yapısal Karakterizasyonları Ve Çeşitli Kanser Hücreleri Üzerinde Sitotoksik/Antikanser Aktiviteleri
CANTÜRK, PAKİZE; Karakuş, Gülderen (20.01.2022)Nanotoksik özellikli poli[Maleik Anhidrit-Ko-Vinil Asetat] kopolimerinin sentezlenmesinden sonra ilaçlar tr için iyi bir taşıyıcı olduğu çeşitli deneysel veri ve analizlerle kanıtlanmıştır. Doksorubisin/Doksorubisin türevi ... -
“Poli[Maleik Anhidrit-Ko-Vinil Asetat] Kopolimerinin Doksorubisin/Doksorubisin Türevi Antikanser İlaçlarla Doğrusal Rasyonel Konjugatlarının Sentezi, Yapısal Karakterizasyonları Ve Çeşitli Kanser Hücreleri Üzerinde Sitotoksik/Antikanser Aktiviteleri”
Doç. Dr. Gülderen KARAKUŞ (20.01.2022)Nanotoksik özellikli poli[Maleik Anhidrit-Ko-Vinil Asetat] kopolimerinin sentezlenmesinden sonra ilaçlar için iyi bir taşıyıcı olduğu çeşitli deneysel veri ve analizlerle kanıtlanmıştır. Doksorubisin/Doksorubisin türevi ... -
Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion
Objectives: Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia,the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. ... -
Potential role of immune cell genetic variants associated with tumor microenvironment response in laryngeal squamous cell carcinoma (LSCC) in terms of clinicopathological features
Horozoglu,Cem; Sonmez, Dilara; Demirkol, Seyda; Hakan, Mehmet Tolgahan; Hepokur, Ceylan; Verim, Aysegul; Yaylim, Ilhan (20 October)Immunomodulatory signals regulate the self-tolerance, activation, priming and survival processes of T cells. Programmed cell death protein 1 (PD1), Programmed death-ligand 1 (PD-L1) inhibitory signals and CD27, CD28 ... -
Preparation and evaluation of a propolis ointment for skin nourishing and healing
Sönmez Gürer, Eda; Şeker, İbrahim Tuğkan; Esentürk Güzel, I; Algın Yapar, Evren; Döşler, Sibel. (Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan, 2022)Propolis is a resinous substance containing aromatic acids, esters, volatile compounds, hydrocarbons, steroids, enzymes, flavonoids, vitamins and minerals. In this direction it has nutrient, antibacterial and antioxidant ... -
Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells
Ay,Ebru Nur; Caner,Armağan; Hepokur,Ceylan; Danişman Kalindemirtaş,Ferdane; Eroğlu, Güneş Özen; Kariper,Afşin (2023)The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various meth ods were used to characterize ... -
Pulicaria Gaertn. Cinsinin Bazı Türleri Üzerinde Yapılan Güncel Araştırmalar
Özpınar, Hülya (Gece Kitaplığı, Eylül 2021)Pulicaria cinsi Asteraceae familyası içerisinde yer almaktadır ve ilk kez 1791 yılında Gaertner tarafından tanımlanmıştır. Asya, Avrupa, Afrika ve Arap yarımadasında dağılım göstermektedir (Anderberg, 2009). Yeryüzünde ... -
Pyrazolyl‐Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
Koca, İrfan; Kamaci, Volkan; Sert,Yusuf; Özsoy,Ceylan; Kani,İbrahim; Tutar, Lutfi; Tutar, Yusuf (2022)Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to ... -
Removal of sulfadiazine from aqueous solution by magnetic biochar prepared with pomegranate peel
Tülay Oymak, Elif Sena Safak (Taylor&Francis, 17/05/2022)Magnetic biochar (Fe3O4-BCPP) was prepared by using iron oxide nanoparticles, and biochar which is obtained from pomegranate peel. The Fe3O4-BCPP were characterized by Brunauer-Emmett-Teller analysis, X-ray diffraction ... -
Selective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells
Paclitaxel (PTX) is one of the most effective drugs in the treatment of cancer. However, its usability is limited due to low solubility and side effects. In this study, we investigated anticancer effects of PTX bonded ... -
Sensitive determination of Anastrozole and Letrozole in urine samples by novel magnetic nanoparticles containing tetraethylenepentamine (TEPA) prior to analysis by high-performance liquid chromatography-diode array detection
Ulusoy, Songül; Locatelli, Marcello; Tartaglia, Angela; Kabir,Abuzar; Ulusoy, Halil İbrahim (Springer, 20.02.2022)Magnetic solid-phase extraction coupled to high-performance liquid chromatography (HPLC)-diode array detection method has been developed for the sensitive analysis of Anastrozole (ANA) and Letrozole (LET) in human urine ... -
Sensitive determination of Fluoxetine and Citalopram antidepressants in urine and wastewater samples by liquid chromatography coupled with photodiode array detector
A new analyte separation and preconcentration method for the trace determination of antidepressant drugs, Fluoxetine (FLU) and Citalopram (CIT) in urine and wastewaters, was developed based on HPLC-DAD analysis after ... -
Sensitive determination of Fluoxetine and Citalopram antidepressants in urine and wastewater samples by liquid chromatography coupled with photodiode array detector
Sarıkaya,Merve; Ulusoy, Halil İbrahim; Morgül, Ümmügülsüm; Ulusoy, Songül; Tartaglia, Angela; Ulusoy, Songül; Soylak, Mustafa; Locatelli, Marcello; Kabir,Abuzar (Elsevier, 26.04.2021)A new analyte separation and preconcentration method for the trace determination of antidepressant drugs, Fluoxetine (FLU) and Citalopram (CIT) in urine and wastewaters, was developed based on HPLC- DAD analysis after ... -
Synthesis and biological evaluation of thiosemicarbazone derivatives
Doğan, Murat; Koçyiğit,Ümit M.; Gürdere,Meliha B.; Ceylan,Mustafa; Budak,Yakup (Springer US, 2022/07/21)In this study, firstly, 22 thiosemicarbazone derivatives (3a-y) were synthesized. Then, ADME parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal chemistry of these molecules were ... -
Synthesis and Molecular Docking of New N-Acyl Hydrazones- Benzimidazole as hCA I and II Inhibitors
Eczacılık Fakültesi (20.01.2023)Background: The carbonic anhydrases (CAs) which are found in most living organisms is a member of the zinc-containing metalloenzyme family. The abnormal levels and activities are frequently associated with various diseases ... -
Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies
Bilgiçli, Ahmet T.; Genc Bilgicli,Hayriye; Hepokur,Ceylan; Tüzün,Burak; Günsel, Armagan; Zengin, Mustafa; Yarasir,M. Nilüfer (2021)In this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1) and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2) were prepared. Then, the novel type metallophthalocyanines ... -
Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects
Alagöz,Mehmet Abdullah; Karakurt,Arzu; Hepokur, Ceylan; Salva, Emine; Önkol, Tijen; Ghoneim, Mohammed M.; Abdelgawad, Mohamed A.; Khames, Ahmed; Kim,Hoon; Mathew,Bijo (2021): In this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities of the compounds were ... -
Synthesis, and docking studies of novel tetrazole S-alkyl derivatives as antimicrobial agents
Çevik, Ulviye Acar; Çelik, İsmail; Işık, Ayşen; Gül, Ülküye Dudu; Bayazıt, Gizem; Bostancı, Hayrani Eren; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis, 01.09.2022)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ... -
Synthesis, and docking studies of novel tetrazole-S-alkyl derivatives as antimicrobial agents
Eczacılık Fakültesi (07.01.2023)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ...