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Now showing items 31-35 of 35
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
(03.10.2023)
In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ...
Investigation of the effect of sugammadex on glutamateinduced neurotoxicity in C6 cell line and the roles played by nitric oxide and oxidative stress pathways
(August 202)
This experiment was intended to evaluate the effect of sugammadex on the
cytotoxicity induced by glutamate, involving the nitric oxide and oxidative
stress pathways. C6 glioma cells were used in the study. Glutamate ...
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16. 08. 20)
Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic
cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ...
The Role of Nitric Oxide Pathway in the Anti-Epileptogenic Effect of Valproic Acid in the Pentylenetetrazole-Kindling Model in Rats
(02. 06. 20)
Though valproic acid (VPA) is used to treat seizures, more investigations have been needed to understand the effect of VPA on the nitric oxide pathway in epilepsy. Our investigation aimed to study the effect of VPA on ...
Application of magnetic solid‑phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
(Şubat, 202)
Background The analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of
human life and therapeutic effects. For this purpose, a new magnetic sorbent was developed ...